Nucleosides and nucleotides. 95. Improved synthesis of 1-(2-azido-2-deoxy-β-D-arabinofuranosyl)cytosine (cytarazid) and -thymine. Inhibitory spectrum of cytarazid on the growth of various human tumor cells in vitro

Article abstract of DOI:10.1021/jm00107a018

Reaction of N³-benzoyl-1-[3,5-O-(tetraisopropyldisiloxan-1,3-diyl)- β-D-ribofuranosyl]thymine (4a) with diphenyl phosphorazidate, diethyl azodicarboxylate, and triphenylphosphine in tetrahydrofuran afforded N³-benzoyl-1-[2-azido-2-de