A Simple, Chiral-Pool-Independent Synthesis of Enantiomerically Pure Alanine-Derived α-Amino Aldehyde Acetals

Article abstract of DOI:10.1055/s-1989-27331

Enantiomerically pure (R)- or (S)-1,1-dialkoxy-2-propanamines 5 are obtained in good chemical and optical yields, by asymmetric reduction of chiral imines prepared from 1,1-dialkoxy-2-propanones, using (R)- or (S)-1-phenylethylamine ((R)- or (S)-2) as an