Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models

Article abstract of DOI:10.1111/j.2042-7158.2011.01289.x

Objectives The aim of this study was to investigate drug release from a double steroid prodrug, OPN501, which incorporates a phenylpropionate linker, and its phenylacetate analogue. The prodrugs, which were designed to deliver prednisolone to the colon fo