Towards a new type-of HMG-COA reductase inhibitor

Article abstract of DOI:10.1016/S0040-4020(01)87862-5

In an attempt to design a novel class of HMG-Co A reductase inhibitors, we have synthesized compound as a reaction intermediate analogue of the enzymatic reduction of mevaldic acid by NADPH. A 15 steps, enantioselective sequence allowed us, from commercial R-(+)-malic acid to prepare aldehyde in an optically pure form and to couple it with the nicotinamide moiety affording the target molecule.