Angewandte Chemie - International Edition p. 3354 - 3357 (2012)
Update date:2022-08-02
Topics:
Can, Daniel
Spingler, Bernhard
Schmutz, Paul
Mendes, Filipa
Raposinho, Paula
Fernandes, Celia
Carta, Fabrizio
Innocenti, Alessio
Santos, Isabel
Supuran, Claudiu T.
Alberto, Roger
Enhanced receptor selectivity: Carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive 99mTc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)3] (Cp=cyclopentadienyl, M=Re, 99mTc) with R being a highly potent carbonic-anhydrase-targeting vector is reported (see picture). Copyright
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Doi:10.1002/anie.201404154
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(2011)
