ChemMedChem p. 1203 - 1206 (2011)
Update date:2022-08-05
Topics:
Fantacuzzi, Marialuigia
Maccallini, Cristina
Lannutti, Fabio
Patruno, Antonia
Masella, Simona
Pesce, Mirko
Speranza, Lorenza
Ammazzalorso, Alessandra
De Filippis, Barbara
Giampietro, Letizia
Re, Nazzareno
Amoroso, Rosa
Picking your NOS: The effect of amine substitution at the 3-aminomethyl group of known iNOS inhibitor W1400 with mono- or disubstituted benzylic groups was evaluated. The o-nitro-benzyl derivative was identified as a potent inhibitor of iNOS, with good selectivity over eNOS. Docking simulations were performed to predict the binding mode of these derivatives in the iNOS and eNOS active sites.
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Doi:10.1080/00397919208021306
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