Bioorganic and Medicinal Chemistry Letters p. 5268 - 5271 (2012)
Update date:2022-08-05
Topics:
Kuang, Rongze
Wu, Heping
Ting, Pauline C.
Aslanian, Robert G.
Cao, Jianhua
Kim, David W.
Lee, Joe F.
Schwerdt, John
Zhou, Gang
Jason Herr
Zych, Andrew J.
Yang, Jinhai
Lam, Sang Q.
Jenkins, David M.
Sakwa, Samuel A.
Wainhaus, Samuel
Black, Todd A.
Cacciapuoti, Anthony
McNicholas, Paul M.
Xu, Yiming
Walker, Scott S.
A detailed structure-activity relationship study of a novel series of pyridazine-based small molecule glucan synthase inhibitors is described. The optimization of the PK profile of this series led to the discovery of compound 11g, which demonstrated in vivo potency ip in a lethal fungal infection model.
View Morewebsite:http://www.josunpharma.com
Contact:+86-311-80715268 80766839
Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China
Changzhou Qidi Chemical Co., Ltd
website:http://www.czqdhg.com/
Contact:86-519-83382137
Address:128-1-16# HuaYuan Street,Hutang Town,Wujin District,Changzhou City,P.R.China.
Contact:021-36356756
Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
Beijing ZhongDaXinHe Chemical Product Co.,Ltd
Contact:010-52876516
Address:tongzhoubeiyuan
FUJIAN SHANSHUI CHEMICAL CORP.LTD.
Contact:+86-151-59920036
Address:Jinqiao Gareden, jo@fj-xinyi.com
Doi:10.1016/s0020-1693(96)05209-7
(1996)Doi:10.1039/j39680002099
(1968)Doi:10.1021/jm00308a060
(1968)Doi:10.1021/jo971747j
(1998)Doi:10.1021/om0494824
(2005)Doi:10.1021/jm00303a016
(1969)