RESEARCHES ON ANTIVIRAL AGENTS. 2. ENANTIOSPECIFIC SYNTHESIS OF 1,3-DIMETHYL-6-OXIRANYLPYRIMIDIN-2,4-DIONE WITH ANTI-ASFV ACTIVITY.

Article abstract of DOI:10.1016/S0957-4166(00)86348-X

Chiral epoxide (+)2 has been synthetized in very good yield and high enantiomeric excess via a modified Solladie procedure starting from commercially available orotic acid.Chiral HPLC chromatographic analysis and 300 MHz 1H-NMR with the addition of chiral shift reagent Eu(hfc)3 of compound (+)2 are also reported.