Journal of Medicinal Chemistry p. 798 - 806 (1991)
Update date:2022-08-05
Topics: Synthesis IC50 Scaffold Analogues Inhibitor Docking Studies Structure-Activity Relationship (SAR) Phosphorylation In vitro assay Flavonoid Chromatography (HPLC, TLC) Cell proliferation assay Spectroscopy (NMR, IR, MS)
Cushman, Mark
Nagarathnam, Dhanapalan
Burg, Debra L.
Geahlen, Robert L.
Treatment of o-hydroxyacetophenones 2a-e with excess lithium bis(trimethylsilyl)amide followed by dialkyl carbonates gave 3-(2-hydroxyaryl)-3-oxopropanoates 3a-e.The latter substances were transformed through the reaction of their magnesium chelates with
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