Journal of Medicinal Chemistry p. 1468 - 1475 (1991)
Update date:2022-09-26
Topics:
Schepdael, A. Van
Delcourt, J.
Mulier, M.
Busson, R.
Verbist, L.
et al.
The clinical use of the potent, wide-spectrum aminoglycoside antibiotics is limited by oto- and nephrotoxicities.The latter is related to the binding of these polycationic drugs to negatively charged phospholipids and to the subsequent inhibition of lysos
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