Nucleophilic ring opening of 3-benzyl-1,3-oxazinanes by Reformatsky reagents. A synthesis of β-amino ester derivatives

DOI: 10.1055/s-1990-27092

Source and publish data:

Synthesis p. 1057 - 1058 (1990)

Update date:2022-07-29

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Authors:

Alberola

Alvarez Alvarez

Andres Andres

Gonzalez

Pedrosa Pedrosa

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Article abstract of DOI:10.1055/s-1990-27092

2-Substituted 3-benzyl-1,3-oxazinanes react with the Reformatsky reagent derived from ethyl 2-bromoacetate and zinc, using very mild conditions (0°C, 1 h) leading regioselectively to 3-substituted ethyl 3-[(3-hydroxypropyl)benzylamino]propanoates in high yield.

Full text of DOI:10.1055/s-1990-27092

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