Bioorganic and Medicinal Chemistry Letters p. 4716 - 4719 (2011)
Update date:2022-09-26
Topics:
Kunicki, Joseph B.
Petersen, Mark N.
Alexander, Leslie D.
Ardi, Veronica C.
McConnell, Jeanette R.
McAlpine, Shelli R.
Described are the syntheses of three sansalvamide A derivatives that contain biotinylated tags at individual positions around the macrocycle. The tagged derivatives indicated in protein pull-down assays that they bind to Hsp90 at the same binding site (N-Middle domain) as the San A-amide peptide. Further, these compounds inhibit binding between Hsp90 and multiple C-terminal client proteins. This interaction is unique to the San A analogs indicating they can be tuned for selectivity against Hsp90 client/co-chaperone proteins.
View MoreContact:027-87677569
Address:Room 2203, yujingmingmen Buidling One, xiongchu Road, wuhan city, hubei province, China
Beijing Greenchem Technology Co.,Ltd. ( Panjin Greenchem Technology Co.Ltd .)
website:http://www.bjgreenchem.com/
Contact:+86-427-6515887
Address:301,302, 3rd Floor, Building C-7, Dongsheng Science Park, Northern Territory, Zhongguancun, No. 66, Xixiaokou Road, Haidian District, Beijing
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
website:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Tangshan Moneide Trading Co., Ltd.
Contact:+86-315-8309571
Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Doi:10.1016/S0040-4020(98)00965-X
(1998)Doi:10.1016/S0040-4039(00)85034-0
(1986)Doi:10.1016/j.tetasy.2008.09.009
(2008)Doi:10.1016/j.bmc.2008.08.047
(2008)Doi:10.1246/cl.1996.217
(1996)Doi:10.1007/s00044-013-0887-7
(2014)