New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6″. Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation

Article abstract of DOI:10.1021/jm00108a037

Substitution of the C-1 atom in the 2-deoxystreptamine moiety of gentamicin C₂, a broad-spectrum aminoglycoside antibiotic, by an axial hydroxymethyl group has been reported to confer protection against most clinically important bacterial enzym