Stereoselective synthesis of β-hydroxyamino acids by aldol reaction of α-isocyanocarboxylate with arene-chromium-tricarbonyl complexes

Article abstract of DOI:10.1016/S0040-4039(00)97020-5

High diastereoselectivity is obtained during the addition of ethyl isocyanoacetate 1 to chiral complexes 2 and 3. The 2-oxazoline-4-carboxylic esters are intermediates for the synthesis of β-substituted serines in a stereoconservative process.