Bioorganic and Medicinal Chemistry Letters p. 2611 - 2615 (2011)
Update date:2022-08-02
Topics:
Wu, Chunrui
Miller, Patricia A.
Miller, Marvin J.
A series of analogs of the amamistatin natural products was designed and synthesized to facilitate additional anticancer structure-activity relationships. The results indicate that the anticancer activity is relatively independent of stereochemistry, ester or amide linkage and replacement of the oxazoline/oxazole based iron-binding group with a catechol.
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