Latent Inhibitors. Part 7. Inhibition of Dihydro-orotate Dehydrogenase by Spirocyclopropanobarbiturates

DOI: 10.1039/P19900003137

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 3137 - 3144 (1990)

Update date:2022-08-04

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Authors:

Fraser, William

Suckling, Colin J.

Wood, Hamish C. S.

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Article abstract of DOI:10.1039/P19900003137

A series of 5-spirocyclopropanobarbiturates bearing alkyl and aryl substituents on the cyclopropane ring has been synthesized.Dihydro-orotate dehydrogenase from Clostridium oroticum was shown to be inhibited by these compounds.A related series of 5-member

Full text of DOI:10.1039/P19900003137

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