High-affinity DNA targeting using readily accessible mimics of N2′-functionalized 2′-amino-α-L-LNA

DOI: 10.1021/jo201095p

Source and publish data:

Journal of Organic Chemistry p. 7119 - 7131 (2011)

Update date:2022-07-29

Topics:

Authors:

Karmakar, Saswata

Anderson, Brooke A.

Rathje, Rie L.

Andersen, Sanne

Jensen, Troels B.

Nielsen, Poul

Hrdlicka, Patrick J.

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Article abstract of DOI:10.1021/jo201095p

N2′-Pyrene-functionalized 2′-amino-α-L-LNAs (locked nucleic acids) display extraordinary affinity toward complementary DNA targets due to favorable preorganization of the pyrene moieties for hybridization- induced intercalation. Unfortunately, the synthes

Full text of DOI:10.1021/jo201095p

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