A sustainable synthesis of 2-benzoxazyl and 2-benzothiazyl ketones from alkynyl bromides and 2-amino(thio)phenols promoted by a recyclable catalytic system

Article abstract of DOI:10.1002/cjoc.201100472

An environmentally and economically sustainable synthesis of 2-benzoxazyl ketones and 2-benzothiazyl ketones through FeCl₃·6H ₂O catalyzed tandem reactions of alkynyl bromides with 2-amino(thio)phenols in [bmim]BF₄ has been developed. Remarkable advantages of this new synthetic strategy include high efficiency, readily available starting materials, and recyclable catalyst and reaction medium. An environmentally and economically sustainable synthesis of 2-benzoxazyl ketones and 2-benzothiazyl ketones through FeCl₃·6H₂O catalyzed tandem reactions of alkynyl bromides with 2-amino(thio)phenols in [bmim]BF₄ has been developed. Remarkable advantages of this new synthetic strategy include high efficiency, readily available starting materials, and recyclable catalyst and reaction medium. Copyright