Synthesis of All Possible Regioisomers of myo-Inositol Tetrakisphosphates

DOI: 10.1039/c39950000011

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Journal of the Chemical Society. Chemical communications p. 11 - 12 (1995)

Update date:2022-09-26

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Authors:

Chung, Sung-Kee

Chang, Young-Tae

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Article abstract of DOI:10.1039/c39950000011

Synthesis of all possible nine regioisomers of IP₄, some of which are implicated as second messengers in the cellular signalling, was accomplished from myo-inositol via its dibenzoate derivatives (IBz₂) as the key intermediates; base-catalysed isomerization of readily available I(1,4)Bz₂ and its derivatives, followed by suitable separation procedures efficiently provided all nine regioisomers of IBz₂.

Full text of DOI:10.1039/c39950000011

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