A novel synthesis of α-aminoaldehydes from glyoxal monoacetal

DOI: 10.1055/s-1990-27128

Source and publish data:

Synthesis p. 1173 - 1176 (1990)

Update date:2022-08-03

Topics:

Authors:

Katritzky

Borowiecka

Fan Fan

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Article abstract of DOI:10.1055/s-1990-27128

Primary and secondary amines condense with benzotriazole and glyoxal monoacetal to give N-substituted 1-(benzotriazolyl)-2,2-diethoxyethylamines 4, which with Grignard reagents readily yield the corresponding 2-aminoalkanal diethylacetal 5. These are easily hydrolyzed to produce α-aminoaldehydes 6.

Full text of DOI:10.1055/s-1990-27128

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