A new synthetic route to (±)-thienamycin via 4-exo trigonal cyclisation of carbamoyl cobalt intermediates

Article abstract of DOI:10.1016/0040-4039(91)80870-C

A new synthesis of (±)-thienamycin (1), based on elaboration of the key intermediate (12) in one step by heating a solution of the carbamoylcobalt salophen (11) in toluene, is described.