Resolution and EPC Synthesis of Both Enantiomers of 2,5-Dimethylbicycloheptan-endo-2-ol, Key Intermediate in the Synthesis of Grandisol.

Article abstract of DOI:10.1016/S0957-4166(00)80532-7

The pure enantiomers of 2,5-dimethylbicyclo<3.2.0>heptan-endo-2-ol, key intermediate in the synthesis of grandisol, have been conveniently prepared by optical resolution with (2S)-(-)- and (2R)-(+)-1-(4-toluenesulphonyl)pyrrolidine-2-carboxylic acid chlor