SRN1-Based Methodology for Synthesis of Naphthylquinolines and Naphthylisoquinolines

Article abstract of DOI:10.1021/jo00007a046

A versatile S_RN1 methodology allows straightforward access to title compounds via two strategies: (A) cross-coupling reactions of halobenzopyridine derivatives with anions from 2-naphthol or conversely of iodonaphthalene with anions from hydroxyquinoline and (B) total synthesis from either acetylchloropyridines in which the acetyl and chloro groups are ortho to each other or o-bromobenzamide treated with anions from acetonaphthone.