Synthesis and antimalarial activity of 2-aziridinyl- and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives

DOI: 10.1021/jm00109a016

Source and publish data:

Journal of Medicinal Chemistry p. 1634 - 1639 (1991)

Update date:2022-08-04

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Authors:

Lin Lin

Zhu Zhu

Divo Divo

Sartorelli

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Article abstract of DOI:10.1021/jm00109a016

A series of 2-aziridinyl- and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives has been synthesized and evaluated for antimalarial activity in vitro against the human malaria parasite, Plasmodium falciparum (Vietnam Smith strain,

Full text of DOI:10.1021/jm00109a016

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Product name:2-aziridinyl-5-[(4'-chlorobenzoyl)oxy]-1,4-naphthoquinone

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