Tetrahedron Letters p. 2483 - 2486 (1993)
Update date:2022-08-02
Topics:
Alvernhe, Gerard M.
Laurent, Andre J.
Drean, Isabelle M. Le
Selmi, Abdelaziz
β-Trifluoromethyl β-chloroacrolein 2 reacts with 2-mercaptoethylamine 3 to produce thiazolidine 5 instead of the expected thiazepine 8.The reason of this behaviour is the formation of the tetrahedral intermediate 6 because of stabilisation by the trifluoromethyl group; an intramolecular substitution takes place faster than a 1,4 addition-elimination process. Key Words: Trifluoromethyl; Michael reaction; regiochemistry; thiazolidine; thiazepine
View MoreBeijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)
Contact:010-52876516
Address:tongzhoubeiyuan
NINGBO PANGS CHEM INT’L CO., LTD.
Contact:+86-0574-27666801
Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Contact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Doi:10.1016/j.cclet.2011.05.022
(2011)Doi:10.1016/j.poly.2011.06.033
(2011)Doi:10.1016/j.bmcl.2014.11.007
(2015)Doi:10.1016/j.cclet.2011.05.021
(2011)Doi:10.1021/ol202187h
(2011)Doi:10.1007/s10593-014-1558-4
(2014)
