An efficient synthesis of a (-)-physostigmine's library for identifying potential anti-Alzheimer's agents

DOI: 10.1002/hlca.201100020

Source and publish data:

Helvetica Chimica Acta p. 1496 - 1505 (2011)

Update date:2022-07-29

Topics:

Authors:

Wu, Yi Wu, Yi

Wang, Fusheng

Song, Hao

Qin, Yong

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Article abstract of DOI:10.1002/hlca.201100020

An efficient route for the synthesis of (-)-physostigmine analogs 1a-1g and 2a-2k is described. Analogs 1a-1g were synthesized via copper(I)-catalyzed cycloaddition between the optically pure azide 10 and a variety of alkynes. Similarly, analogs 2a-2k wer

Full text of DOI:10.1002/hlca.201100020

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