Journal of Medicinal Chemistry p. 1818 - 1822 (1991)
Update date:2022-08-04
Topics: Antimalarials Flavins
Cowden
Halladay
Cunningham
Hunt
Clark
A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.
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