Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl)flavins

DOI: 10.1021/jm00110a009

Source and publish data:

Journal of Medicinal Chemistry p. 1818 - 1822 (1991)

Update date:2022-08-04

Topics: Antimalarials Flavins

Authors:

Cowden Cowden

Halladay

Cunningham

Hunt Hunt

Clark Clark

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Article abstract of DOI:10.1021/jm00110a009

A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.

Full text of DOI:10.1021/jm00110a009

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