Chiral aminal templates: Diastereoselective addition to hydrazones; an asymmetric synthesis of α-amino aldehydes

DOI: 10.1055/s-1995-4042

Source and publish data:

Synthesis p. 1038 - 1050 (1995)

Update date:2022-07-29

Topics: Asymmetric synthesis α-amino aldehydes

Authors:

Alexakis

Lensen Lensen

Tranchier

Mangeney

Feneau-Dupont

Declercq

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Article abstract of DOI:10.1055/s-1995-4042

The monohydrazone of glyoxal may be derivatized into a chiral aminal with diamine 7. The resulting chiral reagent 13 reacts with complete diastereocontrol with organolithium reagents in THF. This sterically controlled reaction may be altered to chelation

Full text of DOI:10.1055/s-1995-4042

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