Synthesis and cytostatic actions of 10- and 11-nitronoracronycins, molecular variations of cytostatically active acronycine

DOI: 10.1002/ardp.19913240202

Source and publish data:

Archiv der Pharmazie p. 67 - 71 (1991)

Update date:2022-09-26

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Authors:

Reisch Reisch

Dziemba Dziemba

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Article abstract of DOI:10.1002/ardp.19913240202

The syntheses of 11- and 10-nitronoracronycine (10 and 11) from 1,3-dihydroxy-10-methyl-5-nitroacridinone (7) or 1,3-dihydroxy-10-methyl-6-nitroacridinone (8), respectively, and 2-chloro-2-methyl-3-butyne are reported. In screening tests with the transplantation tumor leukemia P 388 10, 11, 7 and 1,3-dimethoxy-10-methyl-6-nitroacridinone showed cytotoxicity. 8 and 1,3-dimethoxy-10-methyl-nitroacridinone (5) proved to be inactive.

Full text of DOI:10.1002/ardp.19913240202

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