Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

DOI: 10.1016/j.bmc.2011.08.027

Source and publish data:

Bioorganic and Medicinal Chemistry p. 6135 - 6142 (2011)

Update date:2022-09-26

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Authors:

Vardanyan, Ruben

Kumirov, Vlad K.

Nichol, Gary S.

Davis, Peg

Liktor-Busa, Erika

Rankin, David

Varga, Eva

Vanderah, Todd

Porreca, Frank

Lai, Josephine

Hruby, Victor J.

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Article abstract of DOI:10.1016/j.bmc.2011.08.027

Newly designed bivalent ligands - opioid agonist/NK1-antagonists have been synthesized. The synthesis of new starting materials - carboxy-derivatives of Fentanyl (1a-1c) was developed. These products have been transformed to 'isoimidium perchlorates' (2a-

Full text of DOI:10.1016/j.bmc.2011.08.027

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