Folate analogues. 35. synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of n10-propargyl-5, 8-dideazafolic acid1

DOI: 10.1021/jm00113a011

Source and publish data:

Journal of Medicinal Chemistry p. 2746 - 2754 (1991)

Update date:2022-09-26

Topics:

Authors:

Nair Nair

Edwards Edwards

Kisliuk Kisliuk

Gaumont Gaumont

Dev Dev

Duch Duch

Humphreys

Smith Smith

Ferone Ferone

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00113a011

Structural modifications at the pyrimidine ring and at the C⁹,N¹⁰-bridge region of the thymidylate synthase (TS) inhibitors N¹⁰-propargyl-5,8-dideazafolate (1; PDDF; CB 3717), 2-desamino-N¹⁰-propargyl-5,8-dideaz

Full text of DOI:10.1021/jm00113a011

Products guided by the article

Product name:methyl 4-((prop–2–yn–1–ylamino)methyl)benzoate

Cas No:133933-33-2

R&D Labs maybe for 133933-33-2

Synchemie Co., Ltd.

website:http://www.synchemie.com/

Contact:+86-574-87642758

Address:Room 901, Yinyi Bund Building， 132 Renmin Road
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department

Contact:+86-29-88156413

Address:Jixiang Road 99 Xi'an Shaanxi Province
Luna Chemicals Co.,Ltd.

Contact:+86-570-4336358

Address:No.87 Building,Tianqian,Sidu Town
Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)

Contact:+86 021 50106671

Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park

Relevant to this article

Catalytic, asymmetric, interrupted Feist-Benary reactions of α-tosyloxyacetophenones

Doi:10.1021/ol2026697
(2011)
Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction

Doi:10.1016/j.ejmech.2011.09.043
(2011)
Binuclear palladium complexes supported by bridged pincer ligands

Doi:10.1021/om2008056
(2011)
Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

Doi:10.1016/j.ejmech.2013.01.012
(2013)
Anionic [3,3]-sigmatropic rearrangement of N-phenyl-O-acylhydroxylamines to o-aminophenylcetic acids

Doi:10.1016/0040-4039(91)85091-I
(1991)
DABO boronates: Stable heterocyclic boronic acid complexes for use in suzuki-miyaura cross-coupling reactions

Doi:10.1055/s-0030-1261218
(2011)

Article Doi