Folate analogues. 35. synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of n10-propargyl-5, 8-dideazafolic acid1

DOI: 10.1021/jm00113a011

Source and publish data:

Journal of Medicinal Chemistry p. 2746 - 2754 (1991)

Update date:2022-09-26

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Authors:

Nair Nair

Edwards Edwards

Kisliuk Kisliuk

Gaumont Gaumont

Dev Dev

Duch Duch

Humphreys

Smith Smith

Ferone Ferone

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Article abstract of DOI:10.1021/jm00113a011

Structural modifications at the pyrimidine ring and at the C⁹,N¹⁰-bridge region of the thymidylate synthase (TS) inhibitors N¹⁰-propargyl-5,8-dideazafolate (1; PDDF; CB 3717), 2-desamino-N¹⁰-propargyl-5,8-dideaz

Full text of DOI:10.1021/jm00113a011

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