A rapid, high-yield method for 5'-hydroxyl protection in very reactive and amino group modified nucleosides using dimethoxytrityl tetrafluoroborate

Article abstract of DOI:10.1080/07328319608002032

The conventional method for 4,4'-dimethoxytrityl (DMT) etherification of the 5'hydroxyl termini in deoxynucleosides that are either highly reactive or those bearing modifications at the exocyclic amino group can be quite problematic, and in several cases

Full text of DOI:10.1080/07328319608002032

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Nucleosides and Nucleotides
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A Rapid, High-Yield Method for
5′-Hydroxyl Protection in Very
Reactive and Amino Group Modified
Nucleosides Using Dimethoxytrityl
Tetrafluoroborate
Mahesh K. Lakshman a & Barbara Zajc b
a Chemsyn Science Laboratories , 13605 West 96th Terrace,
Lenexa, KS, 66215
b Department of Chemistry , University of Ljubljana , Aškerceva
5, 61000, Ljubljana, Slovenia
Published online: 15 Aug 2006.
To cite this article: Mahesh K. Lakshman & Barbara Zajc (1996) A Rapid, High-Yield Method
for 5′-Hydroxyl Protection in Very Reactive and Amino Group Modified Nucleosides Using
Dimethoxytrityl Tetrafluoroborate, Nucleosides and Nucleotides, 15:5, 1029-1039, DOI:
10.1080/07328319608002032
To link to this article: http://dx.doi.org/10.1080/07328319608002032
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