Chemical and Pharmaceutical Bulletin p. 1746 - 1752 (1991)
Update date:2022-07-29
Topics:
Yamakawa
Matsukura
Nomura
Yoshioka
Masaki
Igata
Okabe
A series of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines was synthesized and evaluated for its biological activity against H+/K+-ATPase prepared from rabbit stomach and gastric acid secretions in Heidenhain pouch dogs. Monoalkyl substituents on the nitrogen atom of the aniline moiety markedly inhibited the enzyme activity to the same degree as omeprazole, a representative H+/K+-ATPase inhibitor. Most of these compounds, administered at 3 mg/kg i.v. inhibited histamine-stimulated gastric acid secretion. The inhibitory activity of these derivatives on the enzymes at pH 6.0 was more potent than that at pH 7.4, and was distinctly correlated to stability in aqueous solution at pH 5.0.
View MoreAirsea(Taizhou) Pharmaceutical Limited(expird)
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Shanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
Xi'an Galaxy Chemicals CO., Ltd
Contact:86-29-89380370
Address:No.8, Gaoxin three road, Xi'an city.
Contact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Doi:10.1039/c1dt10615e
(2011)Doi:10.1021/np2006378
(2011)Doi:10.1080/10426507.2017.1390459
(2018)Doi:10.1002/poc.1836
(2011)Doi:10.1016/0022-328X(91)86189-W
(1991)Doi:10.1021/jo00014a053
(1991)