Hypersensitive acid-labile (HAL) tris(alkoxy)benzyl ester anchoring for solid-phase synthesis of protected peptide segments

Article abstract of DOI:10.1016/S0040-4039(00)74475-3

The novel 5-(4-hydroxymethyl-3,5-dimethoxyphenoxy)valeric acid (HAL) handle has been prepared and applied to solid-phase peptide synthesis using 9-fluorenylmethyloxycarbonyl(Fmoc) for N(α)-amino protection and tert-butyl ethers, esters, and urethanes for