Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3--cyano-2- pyridones from ethyl 3-oxo-2-(substituted phenylazo)butanoates

Article abstract of DOI:10.2298/JSC100618044D

A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2--pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)butanoates and cyanoacetamide in acetone using potassium hydroxide as a catalyst by simple refluxing the reaction mixture. The structure of these dyes was confirmed by FT-IR, NMR and UV-Vis spectroscopy. Copyright 2011 (CC) SCS.

Full text of DOI:10.2298/JSC100618044D

J. Serb. Chem. Soc. 76 (4) 499–504 (2011)
JSCS–4136
UDC 547.235+547.828+547.491:
66.095.3.095.252
Short communication
SHORT COMMUNICATION
Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3-
-cyano-2-pyridones from ethyl 3-oxo-2-(substituted
phenylazo)butanoates
JASMINA DOSTANIĆ1, NATAŠA VALENTIĆ2#, GORDANA UŠĆUMLIĆ2#
2
#
*
and DUŠAN MIJIN
1Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Department of
Catalysis and Chemical Engineering, Njegoševa 12, 11000 Belgrade and 2Faculty of
Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120 Belgrade, Serbia
(Received 11 June, revised 22 November 2010)
Abstract: A new procedure for the synthesis of known azo pyridone dyes is
presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-
-pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)buta-
noates and cyanoacetamide in acetone using potassium hydroxide as a catalyst
by simple refluxing the reaction mixture. The structure of these dyes was con-
firmed by FT-IR, NMR and UV–Vis spectroscopy.
Keywords: azo compounds; cyclocondensation reaction; cyanoacetamide; pyri-
done.
INTRODUCTION
Azo pyridone dyes are important pyridone derivatives that have largely re-
1,2
placed yellow disperse dyes based on pyrazolones due to their bright hues. Py-
ridone disperse yellow dyes, such as C.I. Disperse Yellows 114, 119 and 211, are
3,4
used for dyeing polyester fabrics. The conventional reaction route for the pre-
paration of these azo dyes comprises the reaction of pyridone as a coupling com-
5–16
ponent and various diazonium salts.
Alternatively, arylazo colorants contain-
ing pyridone rings can also be prepared from β-diketones and various diazonium
17,18
salts followed by condensation with cyanoacetamide.
Recently, a microwave
procedure for the synthesis of azo pyridone dyes using the second reaction route
19
was reported.
*Corresponding author. E-mail: kavur@tmf.bg.ac.rs
# Serbian Chemical Society member.
doi: 10.2298/JSC100618044D
499
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2011 Copyright (CC) SCS

500
DOSTANIĆ et al.
Herein, a conventional synthesis of certain 5-(substituted phenylazo)-6-hyd-
roxy-4-methyl-3-cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenylazo)-
butanoates, obtained from ethyl acetoacetate and diazonium salts, and cyano-
acetamide is reported (Scheme 1).
Scheme 1. Reaction route for the synthesis of certain 5-(substituted phenylazo)-6-hydroxy-4-
-methyl-3-cyano-2-pyridones via ethyl 3-oxo-2-(substituted phenylazo)butanoates
(X = H (3), 4-Me (3), 4-MeO (3), 4-Cl (4), 4-Br (5), 4-NO2 (6), 3-Me (7),
3-Cl (8), 2-MeO (9), 2-Cl (10)).
RESULTS AND DISCUSSION
Characteristic and spectroscopic data of the prepared compounds
1,2-Dihydro-6-hydroxy-4-methyl-2-oxo-5-(phenylazo)-3-pyridinecarbonitrile
2
(1). Orange powder; yield: 33 %; m.p. 285–286 °C (lit. m.p. 288.1 °C, 278–
8
12
–1
–279 °C, 278–280 °C ). FTIR (KBr, cm ): 3447 (NH hydrazo), 3189 (NH he-
1
terocyclic), 2231 (CN), 1688, 1667 (C=O). H-NMR (200 MHz, DMSO-d , δ /
6
/ ppm): 2.51 (3H, s, CH ), 7.29 (1 H, t, J = 7.2 Hz, Ar–H), 7.48 (2H, t, J = 7.5
3
Hz, Ar–H), 7.66 (2H, d, J = 7.2 Hz, Ar–H), 12.04 (1H, s, N–H heterocyclic),
14.55 (1H, s, N–H hydrazone form). UV–Vis (EtOH) (λ
/ nm (log ε)): 399
max
(4.37).
1,2-Dihydro-6-hydroxy-4-methyl-5-[(4-methylphenyl)azo]-2-oxo-3-pyridine-
carbonitrile (2). Orange powder; yield: 12 %; m.p. 277–278 °C (lit. m.p. 284.4
2
8
12
–1
°C, 285–286 °C, 252–254 °C ). FTIR (KBr, cm ): 3478 (NH hydrazo), 3176
1
(NH heterocyclic), 2225 (CN), 1680, 1648 (C=O). H-NMR (200 MHz, DMSO–
–d , δ / ppm): 2.50 (3H, s, CH ), 3.34 (3H, s, ArCH ), 7.29 (2H, d, Ar–H, J = 8.4
6
3
3
Hz), 7.57 (2H, d, Ar–H, J = 8.4 Hz), 12.00 (1H, s, N–H heterocyclic), 14.65 (1H,
s, N–H hydrazone form). UV–Vis (EtOH) (λ
/ nm (log ε)): 433 (4.03), 399
max
(4.12).
1,2-Dihydro-6-hydroxy-5-[(4-methylphenyl)azo]-4-methyl-2-oxo-3-pyridine-
carbonitrile (3). Dark red powder; yield: 11 %; m.p. 270–271 °C (lit. m.p. 272–
8
–1
–273 °C ). FTIR (KBr, cm ): 3435 (NH hydrazo), 3189 (NH heterocyclic), 2225
1
(CN), 1682, 1659 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.51 (3H, s,
6
CH ), 3.36 (3H, s, OCH ), 7.40 (2H, d, J = 7.8 Hz, Ar–H), 7.60 (2H, d, J = 7.8 Hz,
3
3
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SUBSTITUTED PHENYLAZO PYRIDONES
501
Ar–H), 12.08 (1H, s, N–H heterocyclic), 14.36 (1H, s, N–H hydrazone form).
UV–Vis (EtOH) (λ / nm (log ε)): 447 (3.70), 393 (3.90).
max
5-[(4-Chlorophenyl)azo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridine-
carbonitrile (4). Orange powder; yield: 61 %; m.p. 302–303 °C (lit. m.p. 301–
8
12
–1
–302 °C, 288–289 °C ). FTIR (KBr, cm ): 3438 (NH hydrazo), 3142 (NH
1
heterocyclic), 2227 (CN), 1673, 1642 (C=O). H-NMR (200 MHz, DMSO-d , δ /
6
/ ppm): 2.48 (3H, s, CH ), 7.51 (2H, d, J = 9.0 Hz, Ar–H), 7.69 (2H, d, J = 9.0 Hz,
3
Ar–H), 12.06 (1H, s, N–H heterocyclic), 14.16 (1H, s, N–H hydrazone form);
UV–Vis (EtOH) (λ
/ nm (log ε)): 396 (4.12).
max
5-[(4-Bromophenyl)azo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridine-
carbonitrile (5). Orange powder; yield: 53 %; m.p. 308–309 °C (lit. m.p. >300
19
–1
°C ). FTIR (KBr, cm ): 3444 (NH hydrazo), 3136 (NH heterocyclic), 2227
1
(CN), 1673, 1664 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.48 (3H, s,
6
CH ), 7.57 (2H, d, J = 9.0 Hz, Ar–H), 7.67 (2H, d, J = 9.0 Hz, Ar–H), 12.07 (1H,
3
s, N–H heterocyclic), 14.43 (1H, s, N–H hydrazone form). UV–Vis (EtOH) (λ
/ nm (log ε)): 396 (4.32).
/
max
1,2-Dihydro-6-hydroxy-4-methyl-5-[(4-nitrophenyl)azo]-2-oxo-3-pyridinecar-
2
bonitrile (6). Dark orange powder; yield: 54 %; m.p. >320 °C (lit. m.p. 324.0 °C,
8
12
–1
326–327 °C, 326–328 °C ). FTIR (KBr, cm ): 3431 (NH hydrazo), 3116 (NH
heterocyclic), 2227 (CN), 1696, 1672 (C=O). H-NMR (200 MHz, DMSO-d , δ /
1
6
/ ppm): 2.52 (3H, s, CH ), 7.86 (2H, d, J = 9.0 Hz, Ar–H), 8.30 (2H, d, J = 9.0
3
Hz, Ar–H), 12.19 (1H, s, N–H heterocyclic), 14.35 (1H, s, N–H hydrazone form).
UV–Vis (EtOH) (λ
/ nm (log ε)): 340 (4.29).
max
1,2-Dihydro-6-hydroxy-4-methyl-5-[(3-methylphenyl)azo]-2-oxo-3-pyridine-
carbonitrile (7). Orange powder; yield: 51 %; m.p. 257–258 °C (lit. m.p. 266–
12
–1
–268 °C ). FTIR (KBr, cm ): 3454 (NH hydrazo), 3150 (NH heterocyclic), 2218
1
(CN), 1671, 1645 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.35 (3H, s,
6
CH ), 2.49 (3H, s, ArCH ), 7.09 (2H, t, J = 7.2 Hz, Ar–H), 7.21–7.45 (2H, m,
3
3
Ar–H), 12.02 (1H, s, N–H heterocyclic), 14.57 (1H, s, N–H hydrazone form).
UV–Vis (EtOH) (λ / nm (log ε)): 429 (4.37), 399 (4.31).
max
5-[(3-Chlorophenyl)azo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridine-
carbonitrile (8). Orange powder; yield: 33 %; m.p. 298–300 °C (Lit. m.p. 288–
12
–1
–290 °C ). FTIR (KBr, cm ): 3444 (NH hydrazo), 3155 (NH heterocyclic), 2221
1
(CN), 1673, 1642 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.47 (3H, s,
6
CH ), 7.27 (1H, d, J = 9.0 Hz, Ar–H), 7.45 (1H, t, J = 8.0 Hz, Ar–H), 7.57 (2H,
3
d, J = 9.0 Hz, Ar–H), 12.07 (1H, s, N–H heterocyclic), 14.34 (1H, s, N–H
hydrazone form). UV–Vis (EtOH) (λ
/ nm (log ε)): 399 (4.51).
max
1,2-Dihydro-6-hydroxy-5-[(2-methylphenyl)azo]-4-methyl-2-oxo-3-pyridine-
carbonitrile (9). Red powder; yield: 61 %; m.p. 314–315 °C (lit. m.p. 324–325
8
–1
°C ). FTIR (KBr, cm ): 3457 (NH hydrazo), 3142 (NH heterocyclic), 2226
1
(CN), 1672, 1658 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.50 (3H, s,
6
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DOSTANIĆ et al.
CH ), 3.92 (3H, s, OCH ), 7.00–7.33 (2H, m, Ar–H), 7.61 (1H, d, J = 7.2 Hz,
3
3
Ar–H), 7.75 (1H, d, J = 7.4 Hz, Ar–H), 12.06 (1H, s, N–H heterocyclic), 14.91
(1H, s, N–H hydrazone form). UV–Vis (EtOH) (λ / nm (log ε)): 379 (4.23).
max
5-[(2-Chlorophenyl)azo)-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridine-
carbonitrile (10). Orange powder; yield: 28 %; m.p. >320 °C (lit. m.p. 347–348
8
–1
°C ). FTIR (KBr, cm ): 3447 (NH hydrazo), 3168 (NH heterocyclic), 2223
1
(CN), 1675, 1660 (C=O). H-NMR (200 MHz, DMSO-d , δ / ppm): 2.50 (3H, s,
6
CH ), 7.31 (1H, t, J = 8.0 Hz, Ar–H), 7.51 (1H, t, J = 7.4 Hz, Ar–H), 7.63 (1H, d,
3
J = 8.0, Hz Ar–H), 7.90 (1H, d, J = 7.8 Hz, Ar–H), 12.22 (1H, s, N–H hetero-
cyclic), 14.95 (1H, s, N–H hydrazone form). UV–Vis (EtOH) (λ
/ nm (log ε)):
max
423 (4.36).
In comparison to the conventional reaction route for the preparation of the
studied pyridone dyes, which requests the preparation of the starting pyridone
20
(which usually takes about 8 h), and the synthesis of azo compounds (which
2
also takes several hours), the employed reaction route takes less time (about 2–3 h
for the synthesis of the arylazo keto ester and 5 h for the condensation step) but
12
gives, according to literature, lower yields. Although obtained yields are lower
(low to moderate), the obtained raw products were generally of high purity and
the arylazo dyes obtained in such a manner do not contain unreacted pyridone
material, which is present in the first reaction route.
According to the obtained results, electron-attracting substituents in phenyl
group give higher yields while electron-donating substituents give lower yields,
21
which is in accordance with the reaction mechanism of pyridone formation.
The unreacted intermediate can be isolated by washing the solid residue (ob-
tained from the filtrate after isolation of the product) with hot ethanol and used
again for the synthesis of the wanted azo pyridone dye by simple introduction in
a new reaction mixture.
The arylazo pyridone dyes prepared in this work may exist in two tautomeric
8,15
forms: the hydrazone and azo form
(Fig. 1). The infrared spectra of all syn-
Fig. 1. The equilibrium between the hydrazone form (I) and the azo form (II) of
5-(substituted phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones.
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SUBSTITUTED PHENYLAZO PYRIDONES
503
–1
thesized dyes showed two intense carbonyl bands at about 1642 and 1696 cm ,
which were assigned to the diketohydrazone form. The spectra exhibited a broad
–1
N–H hydrazone band in the region 3434–3457 cm which suggests that these
compounds dominantly exist in the solid state in the hydrazone tautomeric form.
1
The H-NMR spectra of the dyes exhibited a signal near 14.16–14.99 ppm.
This signal corresponds to the imino N–H proton resonance of the hydrazone
form. The obtained results are in agreement with the data obtained by Ertan and
12
Gurkan (hydrazone form with N–H peaks in the range of 15.1–15.6 ppm) and
22,23
also by Peng et al.
(hydrazone form with N–H peaks in the range of 14.30–
–16.09 ppm).
EXPERIMENTAL
Materials
All the used materials were obtained commercially, mostly from Fluka, and were used
without further purification.
Equipment
The IR spectra were recorded on a Bomem FTIR Spectrophotometer, MB series, in the
1
form of KBr pellets. The H-NMR spectra were recorded as solutions in DMSO-d6 using a
Varian Gemini-200 instrument, with tetramethylsilane as the internal standard. The UV–Vis
absorption spectra were taken using a Shimadzu 1700 UV–Vis spectrophotometer in 1.00 cm
cells at 25±0.1 °C in ethanol at a concentration of 5×10-5 mol dm-3.
Synthesis of azo pyridone dyes
To a solution of ethyl acetoacetate (0.01 mol) in 30 cm3 of ethanol, sodium acetate (3.0
g) was added. The mixture was cooled to 0 °C and a cooled solution of arenediazonium
chloride (prepared from 0.01 mol of substituted aniline in 5 cm3 of dilute HCl (6 M) and a
solution of NaNO2 (0.0105 mol) in water (4.2 cm3) was added under stirring. The stirring was
continued for one hour after which the solid was collected, washed with 2×5 cm3 of water and
2×5 cm3 of ethanol, and dried in air.
The obtained product (0.01 mol), potassium hydroxide (0.017 mol) and cyanoacetamide
(0.02 mol) were dissolved in 15 cm3 of acetone and stirred and refluxed for 5 h. The resulting
mixture was acidified using dilute HCl, and the solid product was collected by filtration and
washed with 2×5 cm3 of water and 2×5 cm3 acetone. The obtained crystals were then recrys-
tallized from acetone.
CONCLUSIONS
A new simple procedure for the synthesis of 5-(substituted phenylazo)-6-hy-
droxy-4-methyl-3-cyano-2-pyridones is presented. Synthesis from ethyl 3-oxo-2-
-(substituted phenylazo)butanoates in acetone gave products in low to moderate
yields. These dyes exist in the hydrazone tautomeric form in the solid state and in
solvent DMSO-d .
6
Acknowledgments. The authors are grateful to the Ministry of Science and Technological
Development of the Republic of Serbia for financial support (Projects 172013 and III 45001).
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504
DOSTANIĆ et al.
И З B О Д
СИНТЕЗА 5-(СУПСТИТУИСАНИХ ФЕНИЛАЗО)-6-ХИДРОКСИ-4-МЕТИЛ-3-ЦИЈАНО-2-
-ПИРИДОНА ИЗ ЕТИЛ-3-ОКСО-2-(СУПСТИТУИСАНИХ ФЕНИЛАЗО)БУТАНОАТА
ЈАСМИНА ДОСТАНИЋ1, НАТАША ВАЛЕНТИЋ2, ГОРДАНА УШЋУМЛИЋ2 и ДУШАН МИЈИН2
1Institut za hemiju, tehnologiju i metalurgiju, Univerzitet u Beogradu, Centar za katalizu i hemijsko
in`ewerstvo, Wego{eva 12, 11000 Beograd i 2Katedra za organsku hemiju, Tehnolo{ko–metalur{ki
fakultet, Univerzitet u Beogradu, Karnegijeva 4, 11120 Beograd
Нови поступак за синтезу познатих азо-пиридонских боја је описан у раду. Серија 5-(суп-
ституисаних фенилазо)-6-хидрокси-4-метил-3-цијано-2-пиридона је припремљена из етил-3-
оксо-2-(супституисаних фенилазо)бутаноата и цијаноацетамида у ацетону коришћењем ка-
лијум-хидроксида као катализатора уз загревање.
(Примљено 11. јуна, ревидирано 22. новембра 2010)
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