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Potent and selective inhibitors of long chain l-2-hydroxy acid oxidase reduced blood pressure in DOCA salt-treated rats

DOI: 10.1021/ml2001938

Source and publish data:

ACS Medicinal Chemistry Letters p. 919 - 923 (2011)

Update date:2022-08-02

Topics:

Authors:

Barawkar, Dinesh A.Barawkar, Dinesh A.

Meru, AshwinMeru, Ashwin

Bandyopadhyay, AnishBandyopadhyay, Anish

Banerjee, AbirBanerjee, Abir

Deshpande, Anil M.Deshpande, Anil M.

Athare, ChandrashekharAthare, Chandrashekhar

Koduru, ChandrasekharKoduru, Chandrasekhar

Khose, GorakshaKhose, Goraksha

Gundu, JayasagarGundu, Jayasagar

Mahajan, KoshuMahajan, Koshu

Patil, PradeepPatil, Pradeep

Kandalkar, Sachin R.Kandalkar, Sachin R.

Niranjan, SanjayNiranjan, Sanjay

Bhosale, ShubhangiBhosale, Shubhangi

De, SiddharthaDe, Siddhartha

Mukhopadhyay, SuditMukhopadhyay, Sudit

Chaudhary, SumitChaudhary, Sumit

Koul, SummonKoul, Summon

Singh, UmeshSingh, Umesh

Chugh, AnitaChugh, Anita

Palle, Venkata P.Palle, Venkata P.

Mookhtiar, Kasim A.Mookhtiar, Kasim A.

Vacca, JosephVacca, Joseph

Chakravarty, Prasun K.Chakravarty, Prasun K.

Nargund, Ravi P.Nargund, Ravi P.

Wright, Samuel D.Wright, Samuel D.

Roy, SophieRoy, Sophie

Graziano, Michael P.Graziano, Michael P.

Singh, Sheo B.Singh, Sheo B.

Cully, DorisCully, Doris

Cai, Tian-QuanCai, Tian-Quan

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Article abstract of DOI:10.1021/ml2001938

l-2-Hydroxy acid oxidase (Hao2) is a peroxisomal enzyme with predominant expression in the liver and kidney. Hao2 was recently identified as a candidate gene for blood pressure quantitative trait locus in rats. To investigate a pharmacological role of Hao

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Full text of DOI:10.1021/ml2001938

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