Development of a Novel Series of (2-Quinolinylmethoxy)phenyl-Containing Compounds as High-Affinity Leukotriene D4 Receptor Antagonists. 4. Addition of Chromone Moiety Enhances Leukotriene D4 Receptor Binding Affinity

Article abstract of DOI:10.1021/jm00109a025

The combination of the benzopyran-4-one ring, a moiety found in the prototype leukotriene antagonist, FPL 55,712, with the (2-quinolinylmethoxy)phenyl group led to a significant increase in leukotriene receptor binding affinity.This modification resulted