Novel stereoselective synthesis of (-)-enterolactone employing chiral unsaturated lactam

Article abstract of DOI:10.1016/0040-4020(92)85007-2

A novel convergent synthetic methodology of chiral antileukemic lignan lactones was developed by the use of optically active N-alkyl-α,β-unsaturated lactam elaborated from _L-malic acid and the asymmetric synthesis of (-)-enterolactone was accomplished in short and simple steps.