The asymmetric synthesis of β-lactam antibiotics. I. Application of chiral oxazolidones in the Staudinger Reaction

DOI: 10.1016/S0040-4039(00)89250-3

Source and publish data:

Tetrahedron Letters p. 3783 - 3786 (1985)

Update date:2022-08-04

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Authors:

Evans Evans

Sjogren Sjogren

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Article abstract of DOI:10.1016/S0040-4039(00)89250-3

The reactions of oxazolidone with N-benzylimines proceed with exceptional levels of asymmetric induction to form the cycloadducts. Subsequent dissolving metal reduction affords the homochiral β-lactam derivatives in good overall yield.

Full text of DOI:10.1016/S0040-4039(00)89250-3

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