Synthese et etude pharmacologique de quelques aminolactones et aminotetrahydrofuranes adamantaniques

Article abstract of DOI:10.1016/0223-5234(91)90213-7

This paper describes the synthesis of adamantane aminolactones (AdAL 6 and PhAdAL 16) and their tetrahydrofuran analogues (AdAE 9 and PhAdAE 19).Their convulsant activity was studied in mice.It was found to be weaker than that of the aminolactones or aminotetrahydrofurans, which have a phenyl group in place of the adamantane ring.Studies on the antagonism of the convulsant action of these derivatives, by GABAergic or glycinergic agonists appear to show the simultaneous development of dopaminergic, antiGABAergic (for the AdAE and PhAdAE) and antiglycinergic (for theAdAL and PhAdAL) central activities.These properties could be interesting in the treatment of the late stages of the Parkinson's disease.