Tetrahedron p. 12097 - 12108 (1994)
Update date:2022-08-03
Pettit, George R.
Thornton, Timothy J.
Mullaney, Jeffrey T.
Boyd, Michael R.
Herald, Delbert L.
et al.
A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15.Reaction of protected (S)-Hiva-(S)-Phe 2c with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c -> 3
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