Electrophilic amination: First direct transfer of NHBoc with Li t-butyl-N-tosyloxycarbamate

Article abstract of DOI:10.1016/S0040-4039(00)79923-0

Lithium t-butyl-N-tosyloxycarbamate (LiBTOC) has been found to be an electrophilic aminating reagent. This species reacts with organometallic reagents, ester enolates and α-cuprophosphonates to provide primary amines as well as α-aminocarboxylic and phosphonic esters in their N-(Boc) protected form. (35-80% isolated yields).