Organic Process Research and Development p. 284 - 289 (2015)
Update date:2022-08-03
Topics:
Krasutsky, Sergiy G.
Jacobo, Sheila H.
Tweedie, Scott R.
Krishnamoorthy, Ravi
Filatov, Alexander S.
Early process development toward the scalable production of taxadienone on a decagram scale is described. A continuous flow reactor was employed to safely run a potentially hazardous cyclopropane ring opening. The route featured two copper-mediated additions, a Diels-Alder reaction and a palladium-catalyzed Negishi coupling, to construct the final structure.
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