Reaction of 6-Glycopyranosylaminopyrimidin-4-ones with Malonic Acids. Synthesis of 8-Glycopyranosylpyridopyrimidin-4-one Derivatives

Article abstract of DOI:10.1007/BF00810825

Reactions of 6-glycopyranosylaminopyrimidin-4-ones 1a-d with malonic, methyl malonic and ethyl malonic acids are discussed in this paper.These reactions have been carried out in acetic anhydride at 100 deg C affording the 8-glycopyranosylpyrido<2,3-d>pyrimidin-4-ones 2a-d, 3c-d and the 5-acyl-6-glycopyranosylaminopyrimidin-6-ones 4a-d, 5a-d. Keywords.Pyrido<2,3-d>pyrimidines; 8-Glycopyranosylpyrido<2,3-d>pyrimidin-4-ones; Malonic acid derivatives; Nucleosides.