Synthesis of β-(Trifluoromethyl)pyrroles via the Cycloaddition of Munchnones to Electron-Deficient Trifluoromethylated Olefins

DOI: 10.1021/jo00018a011

Source and publish data:

Journal of Organic Chemistry p. 5259 - 5262 (1991)

Update date:2022-08-05

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Authors:

Okano, Takashi

Uekawa, Toru

Morishima, Norihito

Eguchi, Shoji

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Article abstract of DOI:10.1021/jo00018a011

The 1,3-dipolar cycloaddition of munchnones (1,3-oxazolium 5-olates) to β-chloro-β-(trifluoromethyl)vinyl phenyl ketone (1) and butyl β-chloro-γ,γ,γ-trifluorocrotonate (2) gave (trifluoromethyl)pyrroles.The monocyclic munchnones 3a-c yielded the β-(triflu

Full text of DOI:10.1021/jo00018a011

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