Synthesis of the Monofluoro Ketone Peptide Isostere

DOI: 10.1021/jo00016a004

Source and publish data:

Journal of Organic Chemistry p. 4823 - 4826 (1991)

Update date:2022-08-05

Topics:

Authors:

Garrett, Garry S.

Emge, Thomas J.

Lee, Susannie C.

Fischer, Elaine M.

Dyehouse, Karyn

McIver, John M.

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Article abstract of DOI:10.1021/jo00016a004

A synthetic method for the construction of monofluoro ketone peptide isosteres has been realized.The methodology has been employed in a synthesis of the fluoro ketone replacement for the natural substrate for D,D-carboxypeptidase-transpeptidase.

Full text of DOI:10.1021/jo00016a004

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