Synthesis of the Monofluoro Ketone Peptide Isostere

DOI: 10.1021/jo00016a004

Source and publish data:

Journal of Organic Chemistry p. 4823 - 4826 (1991)

Update date:2022-08-05

Topics:

Authors:

Garrett, Garry S.

Emge, Thomas J.

Lee, Susannie C.

Fischer, Elaine M.

Dyehouse, Karyn

McIver, John M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00016a004

A synthetic method for the construction of monofluoro ketone peptide isosteres has been realized.The methodology has been employed in a synthesis of the fluoro ketone replacement for the natural substrate for D,D-carboxypeptidase-transpeptidase.

Full text of DOI:10.1021/jo00016a004

Products guided by the article

Product name:(2R,5S)-6-Benzyloxy-5-methyl-2-(trityl-amino)-hexan-3-one

Cas No:135144-47-7

R&D Labs maybe for 135144-47-7

Luzhou North Chemical Co., Ltd.

Contact:+86-830-2796784；+86-830-2796776

Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
MedicalChem(Yancheng)Manuf.Co.,Ltd.

Contact:+86-515-84383366

Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
Neworld Chemical Co., Ltd Shanghai(expird)

Contact:+86-21-62202658

Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Longhui qunfeng Chemical Co., Ltd

Contact:86-731-82173407

Address:South-east Industrial Park, Longhui County, Hunan Province, China

Relevant to this article

Synthesis of substituted 3-cyano- and 3-(arenesulfonyl)indoles from o-nitrobenzyl cyanides and sulfones

Doi:10.1055/s-0030-1289515
(2011)
Synthesis of multisubstituted cyclopentadienes from cyclopentenones prepared via catalytic double aldol condensation and nazarov reaction sequence

Doi:10.1055/s-0030-1260324
(2011)
A highly efficient large-scale asymmetric Michael addition of isobutyraldehyde to maleimides promoted by a novel multifunctional thiourea

Doi:10.1016/j.tetasy.2011.10.002
(2011)
Three new flavans from the root of Daphne odora THUNB.

Doi:10.1248/cpb.33.416
(1985)
Highly efficient D₂ generation by dehydrogenation of formic acid in D₂O through H⁺/D⁺ exchange on an iridium catalyst: Application to the synthesis of deuterated compounds by transfer deuterogenation

Doi:10.1002/chem.201200576
(2012)
Improvements to the synthesis of isofagomine, noeuromycin, azafagomine, and isofagomine lactam, and a synthesis of azanoeuromycin and guanidine isofagomine

Doi:10.1071/CH06241
(2006)

Article Doi