Bioorganic and Medicinal Chemistry Letters p. 75 - 80 (1998)
Update date:2022-07-29
Topics:
Ogino, Takashi
Tsuji, Kiyoshi
Tojo, Takashi
Igari, Norihiro
Seki, Nobuo
Sudo, Yu
Manda, Toshitaka
Nishigaki, Fusako
Matsuo, Masaaki
A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092,26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.
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