Discovery of FR115092 : A novel antinephritic agent

DOI: 10.1016/S0960-894X(97)10192-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 75 - 80 (1998)

Update date:2022-07-29

Topics:

Authors:

Ogino, Takashi

Tsuji, Kiyoshi

Tojo, Takashi

Igari, Norihiro

Seki, Nobuo

Sudo, Yu

Manda, Toshitaka

Nishigaki, Fusako

Matsuo, Masaaki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10192-5

A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092,26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF₁ mice, and showed none of the blood toxicity observed with dapsone.

Full text of DOI:10.1016/S0960-894X(97)10192-5

Products guided by the article

Product name:N-[2-Methyl-4-(4-nitro-benzoyl)-phenyl]-acetamide

Cas No:135210-16-1

R&D Labs maybe for 135210-16-1

Zha Yan

Contact:+86-13914766747

Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
NanJing KaiHeng Chemical CO., LTD.

Contact:+86-25-85768391

Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Yancheng Creator Chemical Co., Ltd

Contact:0086-515-88710008 88710068 88710858 88710868

Address:No.21 Renming Road, Longgang Town, Yandu County,Yancheng City
Synasia Inc

Contact:17316303296

Address:240 Amboy Ave
Chengdu ZY Biochemical Technology Co., LTD

Contact:0086-28-88680086

Address:170 Qingpu Road, Shouan Town, Pujiang County

Relevant to this article

Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids

Doi:10.1021/acscombsci.7b00096
(2017)
Enantioselective ring-opening reaction of meso-epoxides with ArSH catalyzed by a C₂-symmetric chiral bipyridyldiol-titanium complex

Doi:10.1016/j.tetasy.2007.04.030
(2007)
Remodeling natural products: Chemistry and serine hydrolase activity of a rocaglate-derived β-lactone

Doi:10.1021/ja412431g
(2014)
Substituent electronic effects govern direct intramolecular C-N cyclization of N -(biphenyl)pyridin-2-amines induced by hypervalent iodine(III) reagents

Doi:10.1021/jo501822m
(2014)
Organocatalytic Enantioselective Michael-Addition of Malonic Acid Half-Thioesters to β-Nitroolefins: From Mimicry of Polyketide Synthases to Scalable Synthesis of γ-Amino Acids

Doi:10.1002/adsc.201100458
(2011)
Synthesis of N,N',N'-tri(3,5-dinitro benzenesulfonyl)-1,4,7- triazacyclononane and N,N',N'-tri(3,5-diamino benzenesulfonyl)-1,4,7- triazacyclononane

Doi:10.1080/00397919708004182
(1997)

Article Doi