Discovery of FR115092 : A novel antinephritic agent

DOI: 10.1016/S0960-894X(97)10192-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 75 - 80 (1998)

Update date:2022-07-29

Topics:

Authors:

Ogino, Takashi

Tsuji, Kiyoshi

Tojo, Takashi

Igari, Norihiro

Seki, Nobuo

Sudo, Yu

Manda, Toshitaka

Nishigaki, Fusako

Matsuo, Masaaki

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Article abstract of DOI:10.1016/S0960-894X(97)10192-5

A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092,26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF₁ mice, and showed none of the blood toxicity observed with dapsone.

Full text of DOI:10.1016/S0960-894X(97)10192-5

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