Asymmetric Copper(II)-Catalysed Nitroaldol (Henry) Reactions
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[13]
Other metal salts, such as Cu(OTf)2, CoCl2·6H2O, Co(OAc)2·
4H2O, NiCl2·6H2O and CrCl3·6H2O, were also tested in com-
bination with ligand L1 under identical conditions, but all of
them gave inferior results to CuCl2·2H2O.
Other solvents, such as EtOH, MeCN, MeNO2, CH2Cl2, PhMe
and dioxane, were also tested under identical conditions, but
all of them were found to be inferior to THF.
Other organic bases, such as imidazole, 1-methylimidazole, pyr-
idine, pyrrolidine, morpholine and NMM, were also tested un-
der identical conditions, but none of them was found to be
better than DIPEA.
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Received: June 14, 2011
Published Online: August 24, 2011
Eur. J. Org. Chem. 2011, 6092–6099
© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
www.eurjoc.org
6099