Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring

DOI: 10.1016/j.tet.2011.11.008

Source and publish data:

Tetrahedron p. 534 - 543 (2012)

Update date:2022-08-04

Topics:

Authors:

Barlaam, Bernard

Harris, Craig S.

Lecoq, Jonathan

Nguyen, Ha Thi Hoang

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.tet.2011.11.008

The preparation of 6-aminoquinazolin-4(3H)-ones requires the use of platinum-metal group catalysis on the corresponding C-6-iodo or 6-bromo precursors. Herein, we report to our knowledge the first successful S _NAr reaction directly at the unact

Full text of DOI:10.1016/j.tet.2011.11.008

Products guided by the article

Product name:C₂₂H₂₄FN₃O₃

Cas No:1352718-20-7

R&D Labs maybe for 1352718-20-7

Shanghai Korey Pharm Co.,Ltd.(expird)

Contact:021-61840961 021-61840962

Address:No.157,Zhuguang Rd, Qingpu, Shanghai, China
GreatAp Chemicals Co.Ltd.

Contact:

Address:No.89,Xinhua Road, Langfang City,Hebei China
Beijing Chemdow Co., Ltd

website:http://www.chemdow.com

Contact:0086-10-82435335

Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Yangling Ciyuan biotech Co., Ltd.

Contact:86-15802970736

Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Yangling Ciyuan biotech Co., Ltd.

Contact:86-15802970736

Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District

Relevant to this article

Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand

Doi:10.1016/j.bmc.2011.10.046
(2011)
Regulation of diastereoselectivity in the carbocyclization of allenyl (S)-N-tert-butylsulfinimines through a three-component assembly

Doi:10.1021/jo4025072
(2014)
Cu(I)-catalyzed oxidative cyclization of alkynyl oxiranes and oxetanes

Doi:10.1021/ja209866a
(2012)
Interaction of thiazolidine-2-thione with 2,3,5,6-tetrabromo-1,4- benzoquinone: A set of sequential interactions involving redox and substitution reactions after an initial charge transfer complexation

Doi:10.1016/j.saa.2011.10.032
(2012)
A General Synthesis of N-Substituted 2-Azaadamantanes and Their 4,8-Disubstituted Derivatives

Doi:10.1021/jo00330a020
(1981)
Cooperative diastereoselectivity of palladium- and platinum-promoted intramolecular [4+2] Diels-Alder cycloaddition reactions of 3,4-dimethyl-1-phenylphosphole

Doi:10.1021/ic990885j
(2000)

Article Doi