Tetrahedron Letters p. 2589 - 2592 (1991)
Update date:2022-08-04
Topics:
Pansegrau, Paul D.
Anderson, Karen S.
Widlanski, Theodore
Ream, Joel E.
Douglas Sammons
Sikorski, James A.
Knowles, Jeremy R.
The enzyme EPSP synthase, EPSPS, (EC 2.5.1.19) catalyzes an unusual transfer reaction of the enolpyruvoyl moiety from phosphoenol pyruvate (2, PEP) regiospecifically to the 5-OH of shikimate 3-phosphate (1, S3P) to form 5-enol-pyruvoylshikimate 3-phosphate (3, EPSP). Two new inhibitors, (4, and 5) were prepared to probe the S3P binding site.
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Doi:10.1039/c1ob06535a
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