Synthesis and evaluation of two new inhibitors of EPSP synthase

Article abstract of DOI:10.1016/S0040-4039(00)78792-2

The enzyme EPSP synthase, EPSPS, (EC 2.5.1.19) catalyzes an unusual transfer reaction of the enolpyruvoyl moiety from phosphoenol pyruvate (2, PEP) regiospecifically to the 5-OH of shikimate 3-phosphate (1, S3P) to form 5-enol-pyruvoylshikimate 3-phosphate (3, EPSP). Two new inhibitors, (4, and 5) were prepared to probe the S3P binding site.